Cook the macaroni according to the package instructions. Drain and set aside.
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In a large pot, melt the butter over medium heat. Add the flour and whisk continuously to make a roux. Cook for 1-2 minutes until it becomes fragrant.
Gradually whisk in the milk and heavy cream to the roux, ensuring there are no lumps. Continue to whisk until the mixture thickens.
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Reduce the heat to low, then add the cheddar, mozzarella, and Parmesan cheeses. Stir until the cheeses are melted and the sauce is smooth.
Stir in the Dijon mustard, salt, black pepper, garlic powder, onion powder, and paprika.
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Add the cooked macaroni and mixed seafood to the cheese sauce, gently folding until everything is well coated.
Cook for an additional 2-3 minutes until the mixture is heated through.
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Serve the seafood mac and cheese hot, garnished with chopped fresh parsley.
Enjoy your delicious and indulgent seafood mac and cheese!
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